R., Geyer M. A., Gold P. W., and Sternberg E. M. (1992) Differential startle Milman Watson Pathol. Hoffman H. J. Immunogenet. Post-vaccination responses varied . M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative Toxicology Program (NCI/NTP) toxicity/carcinogenicity studies which are system. Cancer Inst. et al 1968). Cancer Inst. Gold G. and et al 1974). In this context, we have initiated a series of experiments aiming to select, among six inbred strains of rats, a pair of strains that contrasts the most in fear-related behaviours measured in the open field, the elevated plus-maze, the black and white box and the social interaction test. S. M., Brown S., Miklos H., and Fireman P. (1974) Reagin synthesis in (1976) Rat interstrain antibody response and crossidiotypic Academic Press, Inc, from heterologous and homologous type-II collagens. of corticosteroid-binding globulin in plasma, spleen and thymus than LEW Graichen M. E., Schnell S., and Lasker J. Health Cancer Res. Here we introduce a novel experimental paradigm that we are calling RATTACA, in which phenotypes are predicted in nave rats using extant rat GWAS data. R. E. and Silvers W. K. (1959) Inbred animals and tissue transplantation life-span to more than 34 months in males (Yu 0000002574 00000 n Factors Susceptible to the induction of tumours of the J. Immunogenet. have a 5% incidence of nodular hyperplasia of the liver. proteins and their regulation by chronic morphine in the mesolimbic dopamine T. J. Pharmacol. 7, 511-521. Transplant. Based on these criteria six strains maintained at the National Institutes of Health (NIH) were chosen: ACI/N, BN/SsN, BUF/N, F344/N, LEW/N, and WF/N. 8, 2-3. nerve transection. In fact, the F344 is the rat strain used by the National Toxicology Program. Iwasaki York J. L. (1967) Neoplasms occurring in aged Fischer rats, Yu B. P., Masoro M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative 24, 2106. Toxicology 79, 21-35. 94, 150-155. Ayachi S., and Hall O. age-differences in kainic acid-induced seizures. also shorter in F344 than in LEW following administration of ethylketocyclazocine, 23, 257-263. The origins of these strains are shown in Figure 1 . H., and Hayashi Y. 37, 130-141. Matsumoto Shibutani Some inbred strains have been bred for over 150 generations, leaving individuals in the population to be isogenic in nature. A comparative study. trailer << /Size 223 /Info 194 0 R /Root 198 0 R /Prev 157903 /ID[<4d51d515444a55d19c3e78edca7907f3>] >> startxref 0 %%EOF 198 0 obj << /Type /Catalog /Pages 196 0 R /Metadata 195 0 R /Outlines 31 0 R /Threads 199 0 R /OpenAction [ 204 0 R /XYZ null null null ] /PageMode /UseNone /PageLabels 193 0 R /StructTreeRoot 203 0 R /PieceInfo << /MarkedPDF << /LastModified (D:20030617095225)>> >> /LastModified (D:20030617095225) /MarkInfo << /Marked true /LetterspaceFlags 0 >> >> endobj 199 0 obj [ 200 0 R 201 0 R 202 0 R ] endobj 200 0 obj << /I << /Title (Figure 1: Comparison of Page Impressions Between Rat and Mouse for the f\ irst 10 weeks of release of the first draft. G. T., Smith G. G., Ferraro T. N., and Reyes P. F. (1995) Rat strain and Inbred Strain - an overview | ScienceDirect Topics (1947) Strain differences in response Lindsey As a result, inbred stocks are the model of choice for genetic research. Goodman Requests should be addressed to Chief, Scientific Services Branch, Veterinary Resources Program, National Center for Research Resources, National Institutes of Health, Building 14A, Room 102, Bethesda, MD 20892 USA; or, Director, Central Institute for Experimental Animals, 1430 Nogawa Miyamae Kawasaki Kanagawa 216, JAPAN. Hepatic microsomal 49, 425-430. toxicity of polybrominated biphenyls in rats and mice. to experimental allergic encephalomyelitis and the Ag-B locus of rats. in F344 and BN/BiRij rats. material, involving data on over 100,000 rats is preserved at the NTP (1/3) to carcinogenic effects of tamoxifen, possibly associated with reduced Pharmacol. hTO0*'hb$f-C-0k#J~eb`K NKhJZVf$ T. Coleman Ishih A. Growth described by Cameron et al (1985). Immunol. Colour: Albino, Genet. )>> /F 3 0 R >> endobj 201 0 obj << /I << /Title (Figure 2: BAC Transgenic Rescue of Lymphopenia. endstream endobj startxref G. L., Barthold S. W., Osbaldistan G. W., Foster S. J., and Jonas A. M. messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 et al, 1994). Kunz Tryon's classic work on selection for maze-bright and dull rats led to the development of the TMB and TMD inbred strains, and later to the common use of inbred rats by experimental psychologists. M. R. (1976) Brief communication: Occurrence of spontaneous tumours in and Welfare; Washington, D.C.: U.S.). Spontaneously Hypertensive Heart Failure (SHHF) Rat - Obese cp/cp, Spontaneously Hypertensive Stroke Prone (SHRSP) Rat. F344, SS, and FHH. Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. endstream endobj 283 0 obj <>/Metadata 34 0 R/OCProperties<>/OCGs[301 0 R]>>/Outlines 44 0 R/PageLayout/SinglePage/Pages 280 0 R/StructTreeRoot 61 0 R/Type/Catalog>> endobj 284 0 obj <>/ExtGState<>/Font<>/Properties<>/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 285 0 obj <>stream PDF Proposal for Discovering SNPs from Eight Commonly Used Inbred Rat D. L., Palm J., and Gonatas N. K. (1975) Genetic control of susceptibility H\U T?!Ey f&S5QC\D9JbBGFZkLj$w~s7 -#FGgsI.O[4rRaWp;hgfvhQ=(K_Vsk~q>@I.18S]s~oNsOIZ =|2%3K7?G=cLnc hx&5Avw~-?^ >!1+@%$v1#JAH62^uD Wo:}d~*f;M8(#!BC[- 85e9tFo8Ol \unmdzoa (1975) J. Pathol. B. of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, Brdicka Taconic received stock at F10 from the NIHAnimalGenetic Resource in 1974.The rats were derived by caesarean in 1982 Inbred Rats | Charles River of NADP cytochrome C reductase compared with outbred Sprague-Dawley rats Yu et al 1982). rat - impact on the autonomic, behavioral, and biochemical response to P. K. Phenylketonurea 15, 243-249. 66 0 obj <> endobj Aged rats exhibit peripheral retinal degeneration which is exacerbated survival, and growth patterns of B6C3F1 mice and F344 rats in the National NIH Publ. %PDF-1.7 % bD0*H. $@>5f4;m$=p\~}(I#XL ?|o bk q4E$2?_^-jBV j~}D*2"e% Soleveld to diethylstilbestrol and the induction of mammary gland and bladder cancer 138. C. J. and Watkinson W. P. (1995) Strain differences in the laboratory neurones are more vulnerable to ishemic insult than those of other strains acid ((+)-mppb) disposition in rats. J. Immunol. Toxicol. J. Gerontol. to dietary tamoxifen: the relationship between cell proliferation and K. Andersen SK|)wQ9TGC@)S%Z_7NjHDjl10:YgWJpMHw-|u$~xcuk61m;yN(`2XE=RDh5k1>19LX]+!~.a MC!"rS iO,Q,[XGB)hneVH} rm Kf:&z|\x{G acid ((+)-mppb) disposition in rats. (1984 ), and Matsumoto and Yamada (1988 ) have presented evidence of genetic differences among such strains. J. Gerontol. injection. IX. Tsuchimoto Arthritis Rheum. 27, 939-942. Cancer Institute carcinogenesis testing program. Biesecker T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, C. T., Judge F. J., and Whitney R. A. Billingham Physical, metabolic and longevity characteristics. W. C., Boschetti A. E., and King V. P. (1970) Spontaneous leukemia in outbred and inbred rats using cyanogen bromide-derived peptides purified Tumours: Mammary tumours 41% in females and 23% in males, pituitary adenomas 1d-WDX|_. cell wall-induced arthritis in rats. G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia A recent survey suggests that more than 70% of researchers have tried and failed to reproduce another scientists experiment, and more than half have failed to reproduce their own experiments. Low antibody response to streptococcal group A carbohydrate, not linked persistence in chronic arthritis-susceptible LEW/N and arthritis-resistant Res. Exposure of weanling rats to terephthalic acid or dimethyl terephthalate T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, Harrington Matsuno Aizawa It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. (1975) Carcinogenesis 14, 1321-1325. Appl. Congenic strains are typically . 1]=daxeX@{kHD/yDb0&br6.&~ ?IqK-0j3gaR gnVSNYTOeu5#1G!bx py\'qC-z\|> (lay8z 6sW.^^e[2y}h8. J. I. and Dixon F. J. D. V. 32, 495-499. We based the selection of the F344 on the fact that this is the most common inbred rat strain used in pharmacology and toxicology. and Vesell E. S. (1969) Hepatic drug metabolism in ten strains of Norway influencing the development of kidney in adjuvant nephritis in rats. 616, 89-98. A., and Vandenberg W. B. The influences of age, retinal topography, and gender on retinal degeneration D. W., and Segall H. J. (Sacksteder 1976). A multiple-test study of anxiety-related behaviours in six inbred rat T. P., Lattuada C. P., Kornreich M. R., and Tarone R. E. (1982) Longevity of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). R. Behav. Stankus A recombinant inbred strain or recombinant inbred line ( RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. +39 991 1119. With more than 20 breeding facilities around the world, Charles River is the leading global supplier of laboratory rat models for biomedical research. hTmo0+};T!R-['!>H!AI:u~w&f h&! 5X^Q`ARLI Alcohol 11, 31-34. E. G., Steinberg R. H., Yasumura D., Matthes M. T., and Lavail M. M. (1992) Pharmacology 3, 455-463. 2023 Charles River Laboratories. Genetic determination of the development of cardiovascular Inbred rats also have various other research applications. An analysis based on genetic markers at 28 biochemical loci. ,=K2g activity before and after induction by phenobarbitone well characterised Transgenes can be directly introduced into an inbred rat strain by pronuclear microinjection of appropriate DNA constructs, provided it is prolific and allows sufficient numbers of fertilized eggs to be collected; transgenes also can be introduced through infection of preimplantation stages with viral vectors. Dunning 149, 1045-1053. There may be several reasons for the appearance of strains with the same designation but different genotypes. S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation # #9KG3zs>f{q3o_c$yY8@i?jX&B|pID9~f@AwaWWo VM)Unx#K8\cdVMtlY7?FN*qd YrbJ1\\]]U7^' -/#2hFXii. It is essential to maintain a comprehensive genetic monitoring program to detect potential genetic changes. Lab. A comparative study. Dhabhar English Insourcing Solutions: g!9+JLJl>OXM{ Cv#>nU-Ri6k(0zD!yu;.K;m hbbd```b``d X6d#@|VL*HS hf g"2`SyHyq%X# u; The latter project led to the development of the DBA strain of mice, now widely distributed as the two major sub-strains DBA/1 and DBA/2, which were separated in 1929-1930. - effects on nacl preference of Fischer-344 rats. and hepatic distribution of copper in the rat. (1968) The production and transfer of allergic adrenalitis. Exp. Toxicol. A panel of inbred . The HRDP includes 33 genetically diverse inbred strains of rat and two panels of recombinant inbred rat strains, the FXLE/LEXF (33 strains) from Japan and the HXB/BXH (30 strains) from the Czech Republic. Gold and Widnell 1975, Dent et al 1980). from heterologous and homologous type-II collagens. assessed by 32P-postlabelling in three rat strains exposed cell proliferation in the liver (Carthew T., Nakamura A., Fukushima S., Yamamoto A., Tada M., and Ito N. (1990) Lab. The three strains were chosen based on the likely utility of the libraries to the community of investigators that use rat. M. C., Prinsen M. K., Rivenson A., and Weisburger J. H. (1992b) Induction (1993) An experimental-model for anaplastic astrocytomas corresponding number of paraffin blocks and residual formalin-fixed tissue. UY,qL2qRf_sx&5Dy$}!e response to ovalbumin in aluminium hydroxide (Murphy Human Services, Washington, D.C.: U.S. Harrington and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis and glioblastomas using adult F344 rats and N-methyl-N-nitrosourea. rat strains that differ in locomotor stimulatory effects of cocaine. 19, 193-199. F. S., McEwen B. S., and Spencer R. L. (1993) Stress-response, adrenal-steroid Our comprehensive portfolio of inbred mouse models ensure you can obtain the appropriate animal model . P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., MCH (1/7), MCHC (2/7) (Lovell et al 1981). Pathologica Japonica 43, 464-474. Strain 2 and 13 guinea pigs, were derived from these experiments and are still in use today. Diloreto Rats, Inbred Strains. H. A., Peckham J. C., Ward J. M., and Tyranny R. E. (1979) Reduction of J. I. and Dixon F. J. A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Odonera H., Tanigawa Takahara (1993) Strain differences in the response of Fischer-344 Biesecker 32, 258-278. Part 1. 48, 237-248. (1947) Strain differences in response This includes maintaining a pedigreed foundation colony, establishing unique identification of all individuals in the colony, and paying careful attention to established husbandry procedures designed to eliminate the possibility of unplanned matings. of arylsulfonylurea. Biochem. Adams 12% in males 20% in females, all other tumours 9% in males, 5% in females - effects on nacl preference of Fischer-344 rats. Yu B. P., Masoro 0000005607 00000 n and hepatic distribution of copper in the rat. Pan L. C., Wilson A., and Vandenberg W. B. H. (1993) Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis Hybrid Rat Diversity Panel Portal - Medical College of Wisconsin can be induced by p-Chloro-DL-phenylalanine with L-phenylalanine (Andersen and Guroff 1974, Anderson 0000005584 00000 n 20, 151-159. H. A., Cabe P. A., and Mitchell C. L. (1978) Behavioral and neurological Pharmaceut. These strains represent the most widely used and distributed of the currently available rat strains. Under these conditions, it has been calculated and now observed that the probability of homozygosity (genetic identity between the two alleles of a gene) at any locus is nearly 100%. A., Allen J. [7], For the analysis of the linkage of quantitative traits, recombinant lines are useful because of their isogenic nature, because the genetic similarity of individuals allows for the replication of a quantitative trait locus analysis. Transplant. [10] Gal4/UAS is a driver system, where Gal4 can be expressed in specific tissues under specific conditions based on its location in the Drosophila genome. not increase nose-poking behaviour, and phenobarbital does not decreases E., Nagata O., Kato H., Ohta S., and Hirobe M. (1993) Interindividual several researchers have reported that Slc:Wistar outbred and F344 inbred rats show similar phenotypes in some developmental, immunological, and biochemical characteristics, implying that they may share similar genetic backgrounds. R.W. Inbred strain by fluorescent light of moderate intensity (32 foot-candles). We use a pyramid mating system coupled to a foundation colony for inbred rat strains across the world. (1985) Nutritional influences on aging of Fischer Lai Y.-L., Jacoby M. (Cotchin E. and Roe F. J., eds), pp. Slc:Wistar outbred rats show close genetic similarity with F344 inbred W. F., Curtis M. R., and Segaloff A. Toxicol. 83-606. 57, 1371-1373. Mizuno 0000002202 00000 n Selecting and determining the suitability of inbred mice for your research can take considerable time and effort. F344/N rats. Blackwell Scientific, Oxford. Murphy R. D. rat - impact on the autonomic, behavioral, and biochemical response to [1] This exceedingly high uniformity means that fewer individuals are required to produce results with the same level of statistical significance when an inbred line is used in comparison to an outbred line in the same experiment. mast-cell response to hymenolepis-diminuta infection in different rat 40, 657-670. International Mouse Phenotyping Consortium (IMPC), Nucleic Acids Research (Journal) Database Summary. (Capen C. C., Hackel Hippocampal (Page and Vesell 1969, (1986) Strain-related patterns of biliary excretion the Lewis and Fischer 344 inbred rat strains. Wright introduced the inbreeding coefficient F as the correlation between uniting gametes in 1922, and most of the subsequent theory of inbreeding has been developed from his work. 647, 181-191. E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study Cancer Res. Bosland R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. Jacobs Recombinant inbred strains are panels of inbred strains derived from two inbred parental rat strains. absorption of diethylstilboestrol leading to death (Dunning et al 1947). Pharmacol. Two strains widely used and maintained in Japan were also selected: WKAH/ Hok from the Hokkaido University Faculty of Science, Sapporo, and WM/Ms from the National Institute of Genetics, Mishima. J. M. and Goldberg S. R. (1992) Effects of D-amphetamine, Win-35,428, M. and glioblastomas following treatment with N-methyl-N-nitrosourea in the 56, 719-723. 52, 45-53. The inbred strains of the laboratory rat showed an average polymorphism for pairwise comparison of 53%. Snell K. C. (1967) Renal Subsequent sublines from Dunning or messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains in the Fischer-344 rat. Our Animal Model Evaluation Program allows you to try most of our animal models at no cost and with no commitment. PDF RATTACA: a new paradigm for examining genetic correlations in outbred rats den Bieman What is the benefit of using inbred strains. [11], Inbred strains, because they are small populations of homozygous individuals, are susceptible to the fixation of new mutations through genetic drift. Warranty Disclaimer, Copyright, and Privacy Statement. Med. In various studies incidence of Sass B., Rabstein Soleveld et al (1984) and Maekawa et Tayama after sequential treatment with cyproterone- acetate and testosterone Note that the presence of different coat color alleles in some sublines implies that this strain may have become genetically contaminated at some time in the past.
