Thanks for reaching out. I Didnt Want to Go Bald. The Impact of 5-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health. We wouldnt recommend that any man take the drug, especially not young men. As the name suggests, PFS is most commonly associated with finasteride, which was licensed for the treatment of male pattern baldness in 1997. Indeed, delineating the pathophysiological mechanisms underlying PFS will be of paramount importance to the understanding of this syndrome and to development of potential novel therapeutic modalities. I even told my brother-in-law to stop taking it. It's sold under the brand names Propecia and Proscar. Its awful when a patient doesnt know whats happening, and takes a medication for a specific purpose, but then develops side effects that may be more damaging than its positive effects. 2022 Oct;10(5):100543. doi: 10.1016/j.esxm.2022.100543. These constellations of symptoms constitute the basis for PFS in individuals predisposed to epigenetic susceptibility. They see a woman, they say intellectually, I know I am supposed to be interested in you. The effect of finasteride on dry eye disease, Investigative Ophthalmology & Visual Science, Playing with your sex hormones with Propecia use can play with your sex life, Statement (via Twitter) to medical colleague, Risk of Depression Associated With Finasteride Treatment, Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, Statement (via Twitter) in response to Jagan Kansal, MDs tweet, Thoughts on propecia in young guys causing decreased libido, possibly permanent?, Response (via Twitter) to the top 20 adverse reactions to finasteride filed with the FDA, Taking Propecia or Proscar to Prevent Hair Loss is Associated with Depression, Anxiety, and Sexual Problems, Response via Twitter to the Karolinska Institutet study Association of 5-Reductase Inhibitors With Prostate Cancer Mortality, Response (via iCliniq) to the mother of a 23-year-old male whose dermatologist prescribed finasteride, Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics, Post-Finasteride Syndrome: An Underestimated Phenomenon, Challenge to fellow health professionals via Twitter, Post-Finasteride Syndrome: Efforts to explain persistent symptoms are undermined by poor long term data on harms, Reaction (via Twitter) to publication of the study Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, in JAMA Dermatology, Successful Finasteride Treatment Can Lead to Permanent Problems, Statement (via Twitter) in response to a study titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, Expanding (via Twitter) on a study published in JAMA Dermatology he co-authored, titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride. PFS can start shortly after starting the medication and can possibly last months to years after stopping. A few additional tests you can do include: Hey mate I have just stopped finasteride after 7 yrs on it. From 50UI per day. The best sex strains. But Nobody Warned Me about Finasteride! It is frequently marketed as androgen deprivation therapy for treatment for male pattern baldness. And they know the risks but prefer the hair. Some people actually report dramatic improvements in their symptoms after starting a certain SSRI. Im 3 weeks off cold turkey. The proportion of men taking 5ARIs and experiencing erectile dysfunction is likely around 5 percent. Avoid all environmental plastics and toxins, Cold and hot exposure, such as swimming in a cold river and doing sauna sessions. But be careful, friends. DHEA potently increases androsterone levels, and that is how its thought to lower anxiety. 2022 Mar;8(2):169-170. doi: 10.1159/000518750. : June 21, 2022. I train a lot, heavy resistance, HIIT, play sport, drink very little. A review of 17 randomized controlled trials (including more than 17,000 patients) demonstrated a nearly twofold increase in sexual, ejaculatory and orgasmic dysfunction in young men using Propecia for male pattern hair loss. If a patient absolutely wants to take finasteride, he must sign a form acknowledging that he has been informed about the side effects and is willing to accept them. Sure I can do that for you. And the interesting thing is that the average age of this group was 32 to 34 years old This drug for young men must be taken off the market. Some men appear initially to tolerate finasteride or dutasteride, with adverse effects arising weeks, months or years after starting the drug. wow very helpful articular and explains my symptoms exactly. I think this is what we are seeing here. Now, remember the idea of the testosterone bell curve and damping effects (little testosterone, little growth, more testosterone, more growth, even more testosterone, reduced growth)? As prescribers, our primary duty is to do no harm. He Became Depressed and His Sex Drive Disappeared. By definition, the condition is characterized by sexual dysfunction, somatic symptoms, and psychological disorders that persist after cessation of finasteride treatment. i been suffering for close to a year from just 3 weeks of usage. Do Anti-Baldness Remedies Make You Impotent? HCG and erectile dysfunction: can it cause or help ED? 5-reduced steroids are significantly increased in a hyperthyroid state. My yardstick for treating any patient is, what would I do if this were my own son? Finasteride is a steroid 5-alpha-reductase inhibitor, approved for the treatment of androgenetic alopecia and benign prostate hyperplasia. I want to try HCG 50 UI per day. Do explosive exercises, such as uphill sprints, muscle-ups, jump squats, burpees, etc. With a greater concentration of receptors, the organ becomes more sensitive to testosterone and at a certain point, paradoxically, that sensitivity may shut down. Careers. In the [long] term, if nothing works out, then go for a hair transplant rather than using Finasteride. You may instead use topical minoxidil (Rogaine), which has no known negative effects on male fertility. 2023 Mar 21;24(6):5904. doi: 10.3390/ijms24065904. Does stopping treatment mean the physiological mechanism of testosterone secretion is reset? Therefore, the effects of a subchronic treatment of finasteride.have been evaluated in male rats. One month after the last treatment.changes in neuroactive steroid levels, steroid receptorsand GABA-A receptor subunitswere detected. Frequently asked questions about Post-Finasteride Syndrome - PFSNetwork.org After 15 years of research i also believe mycotoxins are playing a big role in this, mycotoxins damage the grey matter in your brain which would cause dopamine issues, then a cascade of issues from hpa axis dysfunction, gut issues, hormone issues which wont go away under a complete mycotoxin detox is done. Agreed. Optimize thyroid. Aging Male. The patient needs to know that, and to be able to say, Im stopping now. To date, there are no evidence-based effective treatments for PFS. An observational retrospective evaluation of 79 young men with long-term adverse effects after use of finasteride against androgenetic alopecia. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics: November 2021. Some say it's all in the mind, a made-up mythbut those who suffer from it surely know they're not just a hypochondriac. Altered methylation pattern of the SRD5A2 gene in cerebrospinal fluid of post-finasteride patients: a pilot study: Endocrine Connections, July, 2019. Li X, Guo Y, Lu Y, Li H, Yan S, Li H, Li Y. Transl Androl Urol. 200 mg of pregnenalone per day. Finasteride is a 5-alpha reductase inhibitor that's used to treat androgenetic alopecia (a clinical term for male pattern baldness) and benign prostatic hyperplasia (non-cancerous growth of the prostate gland). Hi man, Id use pregnenolone and D-phenylalanine to counter the long term sides. VigoraClinic.com, April 30, 2020. Who would have thought trying to enhance the hairline would cause bigger problems! Reaction to French medical journal Prescrires annual update of drugs to avoid, March 18, 2021. Post Finasteride Syndrome is a HOAX! : r/tressless - Reddit Furthermore, finasteride inhibits CYP3A4 (which is the enzymes that detox finasteride) and that can cause a significant buildup of finasteride in the body over time. Blocking 5 alpha-reductase to any degree in the brain is a crapshoot. Post-finasteride syndrome (PFS) describes persistent sexual, neurological, physical, and mental adverse reactions in patients who have taken finasteride, a 5-alpha reductase type II enzyme inhibitor used to treat hair loss (under the brand name Propecia or generics) and/or enlarged prostate (Proscar or generics). If you are unable to import citations, please contact Keywords: Ipamorelin vs HGH: the biggest downside is, MK-677 and erectile dysfunction: how to use it correctly, Pre-workout induced ED? Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next? Yes, in general its safer with less sides, but some people have reported similar side effects as fin. In addition, many doctors dont understand or even recognize PFS as a real disease and these patients will suffer alone. Reacting To Joe Rogan Talk About Finasteride, DHT And Post - YouTube National Library of Medicine Thanks for helping people with this truly debilitating syndrome, in my case I was an othewise healthy active 66 year old that was prescribed Dudasteride for an enlarged prostate 3 months ago , after 7 weeks I stopped taking the drug and within several days I came down with a host of symptoms. Fertil Steril. Plus, his muscles and joints ached It seemed the finasteride was the culprit. However, PFS is now so prevalent that it has its own foundation, the Post-Finasteride Syndrome Foundation, where you can acquire a great deal of sobering information, enough to make you wonder why anyone would take the drug to begin with. What few people know is that there are 5-R and 3 types of 5-R enzymes and that theyre not only involved in the conversion of testosterone to DHT, but also in the: Many of the benefits of testosterone, such as enhanced insulin sensitivity, reduced catabolism, higher dopamine, increased thyroid hormone production, are mediated by DHT, and blocking DHT production prevents those effects/benefits. Expanding (via Twitter) on a study published in JAMA Dermatology he co-authored, titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, December 7, 2020. Swiss TV network SRF, May 7, 2018. Some recommend andractim, available in Europe (and online). 2021 Nov;7(6):524-526. doi: 10.1159/000514365. Patients considering using these medications should be very careful and speak to a Urologist in person about risks, benefits, and indications of treatment. Yep, the medical system doesnt care about what happens to you. Statement (via Twitter) in response to SWOG Cancer Research Network article titled Finasteride Safe, Long-Term Results Show, May 17, 2018, [Finasterides] potential side effects, especially the long-term side effects of the drug, should be the overriding concerns to both the users and the manufacturer [Finasteride] has the capability to impair male sexual performance, creating the inability to achieve an erection, decreases libido and has the horrifying potential of causing specific birth defects in a developing male fetus., Supposed Miracle Baldness Cure Creates Serious Health Concerns Among Hair Restoration Professionals: Business Wire, December 24, 1997. Do not take finasteride for hair lossDo not take finasteride for any purposeFor many years, Public Citizens Health Research Group has classified both [Proscar and Propecia] as Do Not Use because their benefits do not outweigh their adverse effects. Some might be upregulated and some downregulated, so you might experience heightened serotonin responses. sharing sensitive information, make sure youre on a federal I will not prescribe finasteride to young men with MPB because of the potential side effects. Documentary on German network NDR titled Side Effects of Finasteride Are Underestimated: January 25, 2021. synthesis of bile (5-R specifically), which is essential for the digestion of fat and absorption of fat-soluble vitamins. Treb RM, Luu NC, Gavazzoni Dias MFR, Dutra Rezende H. Skin Appendage Disord. Int J Trichology. But I am actually not interested in you. What Is Post-Finasteride Syndrome? - GoodRx SperlingProstateCenter.com, Aug. 30, 2018. Balding? I think we need to put the [PCPT] trial concerns to rest. And its not worth it. I know how frustrating it can be, but it doesn't have to be.Let me help you identify the missing link, give you clarity and get you to your goal. Response (via Twitter) to the top 20 adverse reactions to finasteride filed with the FDA: April 23, 2021. Statement (via Twitter) in response to a study titled Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A systematic review, Reaction to French medical journal Prescrires annual update of drugs to avoid, I Didnt Want to Go Bald. He Became Depressed and His Sex Drive Disappeared. Regulatory Effects of Thai Rice By-Product Extracts from. Observations performed in a subset of patients treated for male pattern hair loss indicate that persistent sexual side effects as well as anxious/depressive symptomatology have been reported even after discontinuation of finasteride treatment. Also, increased depression, anxiety and suicidal ideation in a subset of men treated with these drugs were commonly reported in a number of studies. [T]here is no known treatment for lifelong PFS. FOIA Accessibility Keep sexual side effects in mind! Bethesda, MD 20894, Web Policies Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia: Journal of Sexual Medicine, November 2016. Statement (via Twitter) in response to Jagan Kansal, MDs tweet, Thoughts on propecia in young guys causing decreased libido, possibly permanent? November 13, 2020. Its something the drug companies had to disclose over the last decade: Difficulty achieving an erection that continues after stopping the medication, side effects that may even be permanent. MeSH They need to be better informed. An official website of the United States government. 2023 Feb 2;12(3):653. doi: 10.3390/plants12030653. You have to choose between hair and sex drive and your personality and your marriage or your partnership Ive tried giving testosterone to patients who are on finasteride at the same time. Sexual, physical, and overall adverse effects in patients treated with 5-reductase inhibitors: a systematic review and meta-analysis. eCollection 2021 Oct. Treb RM, Gavazzoni Dias MFR, Dutra Rezende H. Skin Appendage Disord. The drug.blocks not only the super hormone but also other hormones that affect thinking and psyche, mood and emotions.
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