You got this! Have you ever had an endometrial biopsy to look for infection? Euploid embryos are believed to have higher success rates and a reduced chance of miscarriage. I was put on the Schoyer protocol for stimulation. Feeling more confused than ever. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Criticisms of PGS - FertilityIQ Another thing to consider: Has your doctor done a hysteroscopy? More studies need to be done. Im currently 17 weeks from another FET. At this point I am waiting to start my 5th miscarriage. What is the percentage of PGT normal embryos after 40 - Reddit The results come back as euploid (meaning theres 46 chromosomes), aneuploid (meaning theres a number of chromosomes besides 46) or mosaic (meaning theres a mix of euploid and aneuploid cells). Then she went into all of the horrible statistics with twin pregnancy. Your experience gives me hope so thank you for sharing , - Estradiol patches and to apply 4 of them and change them every 2 days, - progesterone 200mg suppository morning and evening. How Does PGS Testing Work? - Success Rate & Risks - Coastal Fertility The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. The FET process can take a few tries even with a PGS tested embryo. I am hoping number 5 is it. We PGS tested the whole batch of embryos at once at the end of all the retrievals. At this point I am wondering the following: Id say if you feel you want the extra testing, push for it. She was also concerned with the previous doctors aggressive surgery protocols, and my age was also a factor. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Wishing you lots of luck. Or is it worth having the actual tests done? I know in our case our embryos had epigenetic issues which meant that our baby that we miscarried probably had structural issues. The usefulness comes when someone who is starting IVF and considering PGS testing. (2018)found a reduction in clinical pregnancy when embryos were thawed, biopsied and re-frozen (the odds were about half). My RE didnt change a thing between round 1 and round 2, and I didnt do anything differently. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. There isnt much data on it, and 2 of the 3 studies found no difference, so it isnt exactly clear. This was our first trial. This ended up working for me after my biochemical pregnancy. I'm glad we did - because my ERA results were abnormal and I needed 12 more hours of PIO. Please specify a reason for deleting this reply from the community. Are there recent numbers for this comparison? We timed everything to my cycle. One clinic determined IVF with PGS success rates to have a 10% higher pregnancy rate. Note that this is per transfer data. Success rates for graded euploids are given here https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates. It definitely won't hurt to ask your doctors about an antihistamine protocol, I don't remember the exact dosages I took or how long. After I had my 3rd, my doctor and the IVF nurses all pushed for an ERA saying that even though Ive had prior success, that may have just been luck and my optimal window might be different than what I was doing. Most assume theyll get the stats that are reported per transfer without knowing if theyll get eligible blasts or not. Talk about adjusting meds? Mosaics are often transferred after euploid embryos have been exhausted, although there is evidence that low level mosaic transfers are comparable to euploid transfers (see here for a review). Dear T3BK, thank you so much for your reply! This educational content is not medical or diagnostic advice. A recent meta-analysis by Simopoulou et al. I had a chemical pregnancy with my first FET. (2018)looked at about 650 transfers ofPGS tested euploidembryos (based onSNPtechnology) across various ages: So it looks like the success rates hover around 60-70% in most cases, with women >42 having about a 50% live birth rate per transfer. She said that this is something that is prevalent in recurrent pregnancy loss and failed implantations. There was also no difference with Day 7, although the sample size was very small. My RE had said shes usually very cautious when it comes to sending embryos out for PGS testing only because the process can sometimes compromise the embryo itself. Please whitelist our site to get all the best deals and offers from our partners. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. The majority of these studies used double embryo transfers, either when transferring euploid embryos, in the control untested groups, or both. However, I just recently gave birth, so dont give up there are still lots of reasons to be hopeful esp if you make pgs normal blasts. Check here for the full glossary (please excuse the repeated terms!). You have to do whatever you feel comfortable with and its so unfortunate that money plays a huge role in these decisions. Well start with euploids, then mosaics, and end with fully aneuploid embryos. I ended up taking Lovenox and Prednisone and doing an endometrial scratch biopsy and ERA. MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. I asked her can we do bloodwork to see what couldve caused the miscarriage (I.e immune complex, blood clotting disorder or inflammation) and she doesnt think I need to and how we should proceed with the same protocol again and I dont know how to feel about this unable to sleep. I just wanted to know if anyone had a similar experience and if you can share the things you did differently with your second transfer and had success? What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. PGT-A (formerly PGS testing) is a technique that determines the number of chromosomes in the cells of an embryo. During my first IVF cycle, when we only created 2 normal embryos out of 18 eggs (my husband's sperm is great), it seemed like embryo quality would have explained the first two chemical pregnancies. If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. We were hoping for a Christmas miracle however that was short lived. Once they see it on an U/S, I think it becomes a clinical pregnancy. Is it significantly less for a pregnancy with an embryo that tested pgt normal? I did switch clinics in the middle and felt that my new clinic cared more about me and was more aggressive in testing for other things and adding new medications to my cycles. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). Check here for the full glossary (please excuse the repeated terms!). Lack of common pregnancy symptoms like morning sickness or breast soreness after a positive pregnancy test. PGT-M and PGT-A Genetic Screening Before IVF - Verywell Family Live birth rate differences are inconsistent and therefore inconclusive. (The embryo split!) Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I dont know if this is helpful or not but Ive had 4 FETs. When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. A genetically normal embryo has a 70% chance of a positive pregnancy test in any woman, whether she is 20 years old or 40 years old. PGS can increase the rate of clinical pregnancy. Your clinic may have a better idea of how things work in their hands. I wanted to reach out and see if you know a way to find a surrogate on your own, rather than going thru an agency. See the chart below from the CDC (2016 data): In this post well look at the different miscarriage rates that all these types of PGT-A tested embryos have. My first, was a success. A few rounds of heavy- duty antibiotics cleared it up. I am curious to hear other peoples experiences, especially with 6 days blasts. Are you sure you want to block this member? So, all is well! They also reported the number ofblastsbiopsied. My result came with a high risk, 1 in 11 chances of the baby having Down Syndrome. We are currently waiting on the PGS results from the frozens from our third cycle. I also did Neupogen but they still wanted to test for autoimmune disorders. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. But I do have a friend who had 1 embryo shipped from Utah to California for an FET and it was a different clinic that handled the FET. How about a mosaic? Can I ask why they didn't test them on Day 5? Please don't give up! Congratulations on your pregnancy xxx Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Demko et al. They also did a subgroup analysis using this data for age groups <35 and >35. Pre-implantation Genetic Testing for Aneuploidies (also known as PGT-A, or historically known as PGS or CCS) is a diagnostic tool to tell your fertility doctor which embryos are likely to be chromosomally-normal and thus which to transfer. A 2019 multicenter and international RCT (the STAR trial) compared euploid and untested embryo transfers. Then my 3rd transfer and 2nd FET is now my baby boy growing well at 16 weeks 4 days. 2 came back normal. Im so sorry to hear about your losses but so happy with your current miracle. It will involved thawing your embryos, biopsying, then re-freezing and ultimately re-thawing if the embryo is euploid and you want to transfer it. Your doctor sounds JUST like mine did before I switchedpushing surrogacy and unwilling to try anything differently. Im sorry to hear of your loss! I've experienced 3 chemical pregnancies - one naturally (7/2017), one via our 2nd IUI (9/2018), and the third this January after our FET with a PGS tested embryo. Last year I got pregnant from an IUI and miscarried at 8 weeks. There is much better chance of IVF success with PGS testing in women who were over the age of 35. I am thinking of you and truly wish you the best in January , Im sorry for a late response Ive been off the app to work on my mental health. You can check out my summary of the study here. Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. I guess this probably qualifies me as a poor responder which obviously doesn't feel good after all the other issues we've had. Why I Gave My Mosaic Embryo a Chance - The New York Times After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. About 7 months later I transferred a day 7. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Does it still matter? Once I started hearing other people's stories I was shocked at how common it is- more so than I ever would have imagined. I think the ERA is a great idea too. Poor quality embryos are they worth PGS testing? A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Did your RE have you take anything other than progesterone and estrogen and aspirin? The thing we did differently for this one was adding an antihistamine protocol. 2018). I needed additional days of progesterone and that was corrected for my 2nd FET. Thanks! (2014)found no difference inongoing pregnancybetween grades (about 50% for each category). With the second, the only change was to add low dose steroids. I could tell that my dr thought we could just try again but she knew I needed to check something to feel ok with it. If your protocol did not have one or the other perhaps you can ask your RE about it. I just received news today that out of our 14 blastocysts only 4 passed pgs and 1 with no result that we are retesting. I am so frustrated, disappointed, hurt, sad and angry right now. Terms are highlighted every 3rd time to avoid repetition. Success rates with chromosomally normal embryos, complete guide to embryo grading and success rates, https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates, They also found that the chance of getting a complex abnormal embryo increased with age, Graded as excellent (AA) or good (AB or BA) = 50% live birth, Graded as excellent: 84%ongoing pregnancy, 0% miscarriage, Good: 62%ongoing pregnancy, 3% miscarriage, Poor: 36%ongoing pregnancy, 19% miscarriage, Thaw the embryo and culture it until it can be biopsied (this may take a few hours to a day), If the 2nd test comes back euploid and you transfer, another thaw will need to be done. How IVF with PGS is Changing the Fertility Game for Women over Age 35 Was just curious if the percentages of a live birth increase after a positive pregnancy test. While my clinic has had great success with PGS transfers they did say they expect implantation rates to end up averaging 90% for PGS normal embryos and I believe miscarriage rates are also lower. Hi all, Unfortunately this isnt very clear at this point. We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. Both Chemical pregnancies my lining was under 7. After a chemical with 2 PGS normals and two miscarriages around 8 weeks (spontaneous pregnancies) and another failed transfer, I found out I had an infection in my lining that can only be detected by a biopsy. Thank you! Pgs testing results The Bump I also tested positive for anti-thyroid antibodies. In the past PGS was seen as the holy grail - if the chromosomes are normal we should have implantation and a normal pregnancy. However we now understand that the chromosomes are only part of the issue. I may not have that exactly correct but thats how I understood it. Hi! I've read that in a non-IVF pregnancy, the rate of miscarriage is about 21.3% between weeks 5 and 6. My first FET with my only normal embryo was successful but ended at 7.5 weeks with a MMC The devastation was unreal. My husband and I started trying to get pregnant about a year ago (we're both 35). But what about the women who didnt get blasts? is there another clinic in your area you can switch to? Your clinic may have a better idea! If your window is off I would think that could cause chemical pregnancies because the embryo would have a hard time implanting. Have you been tested for APS (antiphosolipid syndrome)? Disclaimer: Any studies presented here may be contradicted by other studies. No clinic ended up quoting more than 60-70% . Low hCG levels. After multiple necessary hysteroscopies, multiple retrievals, multiplefailed transfers, and 2 chemical pregnancies, I finally decided to get a 2nd opinion. I have expressed my concern but my RE believes it is more about the pattern. I am so frustrated and emotional, I am not having any pregnancy symptoms, beside some minor vaginal cramping and sore breast. As for boosting chances with two put back it should not be the trick. Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid Did you ever go through with your day 7 FET? We had 4 blasts tested in our first IVF cycle and 2 were abnormal / 1 mosaic / and then 1 "normal". No PGS testing (2019) STAR trial represents the best data that we have currently, and it shows no benefit with PGT-A reducing miscarriage in the general population. Consult with your doctor before making any treatment changes. Would love to hear if it was successful - fingers crossed . We spent well over 45K to get to this point. Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. This was something that almost all of our embryos had problems with (a high drop off rate of embryos growing in the lab and all were always low rated if they made it to blastocyst stage). Learn more about, Learn About What to Expect's Pregnancy & Baby App. Our RE recommends trying again, but it feels like insanity to try the same thing without changing/adding anything or doing some tests. undefined will no longer be visible to you including posts, replies, and photos. Yeah now Im just rethinking everything. I have however done Intralipid Infusions and taken Neupogen beginning a week before transfer for Autoimmune protocol (although Ive never actually been tested for Autoimmune disorder). Simon et al. Miscarriage is defined as a loss between clinical pregnancy (detection of a gestational sac or heartbeat) and 20 weeks of gestation. The results came back just this week saying that I was "pre-receptive" and recommended one day more of progesterone before doing the transfer to get to a more "ideal" transfer state. Note that this post is current as of July 2022. Note that this paper is still preprint as of Nov 2021. Your story does give me hope and I wish my little one is as strong as yours! Hi everyone. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. You guys have given me so much support and reassurance that I'm not alone in this ordeal. This was my only PGS normal embryo so I have to re-do that as well.. Dear RLM11, so sorry for your losses, I know how devastating it is! It looks like at this time that it's implantation failure rather than abnormal embryos, since we got a good one from the ones we had tested. I expect a call from my RE tomorrow, will ask about both of your suggestions, the immune protocol and antihistamine and see what she thinks . In this post well learn more about IVF with PGS success rates for euploid embryos. Sometimes something as small as a polyp that can be removed, can cause implantation to fail. I am currently 6w5d pregnant, which is the farthest Ive been. 2nd consecutive blighted ovum with PGS normal FET. Anyone - Inspire
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