If meta-analysis is not applicable, we will conduct a systematic narrative synthesis providing information to summarize and explain the characteristics and findings of the included studies. For novel coronavirus pneumonia, the total effective rate of TCM is over 90%.[EB/OL]. Wolters Kluwer Health Lianhua Qingwen Max: 7 days. FDA Phase-II Clinical Study, In 2020, Diagnosis and Treatment Scheme for Novel Coronavirus Pneumonia, jointly issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine For more information, please refer to our Privacy Policy. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health. The Daily Guardian is a renascent Iloilo-based publishing firm and media outfit with bureaus in Kalibo, Boracay, Roxas, Bacolod, Antique, Guimaras, and Manila. Whether a fixed-effects or a random-effects model will be used depends on the results of I2 test for heterogeneity. The DDB, however, had no objections to the product registration ofLHQWwith the Philippine FDA and said that the importer or distributor shall secure the proper license from thePhilippine Drug Enforcement Agency (PDEA) and comply with all regulatory requirements and relevant issuances. National Library of Medicine As a drug, ephedrine is a decongestant and bronchodilator. Chest radiographs. Chinese Journal of pharmacology and toxicology 2015;29:2137. We will judge the each domain as low risk of bias, high risk of bias," or uncertain risk of bias" according to Higgins (2011), and pay particular attention to the risk of bias of cluster-randomised trials. government site. https://news.cgtn.com/news/2020-04-16/Beijing-approves-TCM-drugs-for-COVID-19-PJWgGfRAQg/index.html. Some notable dangerous reactions include heart attacks, strokes, seizures, and sudden deaths. Clinical observation shows that the total effective rate of traditional Chinese medicine is >90%.[15]. Effectiveness and Safety of Lianhua Qingwen Capsules for COVID-19: A Propensity-Score Matched Cohort Study. Pharmacology and clinical research of traditional Chinese medicine 2010;26:214. PMC Please enable it to take advantage of the complete set of features! Why is it important to subscribe? The https:// ensures that you are connecting to the WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba doi: 10.1371/journal.pone.0238828. Therefore, it is necessary to carry out rigorous and objective quality evaluation for different types of clinical research, and the effectiveness analysis results obtained on this basis are more convincing. She can be reached atbandiolateresamayb@gmail.com. China's top respiratory expert, the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. Hermetically sealed,keep in cool and dry places. Dont take this medicine if the description has changed. [28]. 12th-Five Year Plan Special Project of National Major New Drug Development All reports of the randomized controlled trials (RCTs) on Lianhua Qingwen capsule treating influenza Lianhua Qingwen combined with conventional drugs may be a promising therapy for treating common pneumonia and COVID-19 pneumonia. It is reported that the registration number of Lianhua Qingwen Capsules in the Philippines is THPR-50 and the product category is traditional herbal drugs. Experimental study on the anti Coxsackie B4 virus effect of Lianhuaqingwen capsule [J]. [4]. It is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. [Main Ingredients] doi: 10.1097/MD.0000000000021404. < 5 years: not recommended because it may be difficult for young children to swallow capsules. Learn more. Remdesivir in adults with severe, [13]. Product PackingEach box contains 24 capsules in blister packing. Hai Guo, Jin Yang, Jiening Gong, et al. Any disagreement will be resolved by consensus or discussion with a 3rd party (MJL). Second Prize of National Science and Technology Progress Awards Zhang, Xiaolin MDa,; Cao, Di MMb; Liu, Junnan MMa,c; Zhang, Qi MDa; Liu, Mingjun PhDa,, aChangchun University of Chinese Medicine. 2.Its not appropriate to take nourishing chinese medicine wihte taking medicine. How to cite this article: Zhang X, Cao D, Liu J, Zhang Q, Liu M. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. LHQW won the 2nd prize of the National Scientific and Technological Progress Award in 2011 for the treatment of influenza. The Authors. Efficacy and safety of Lianhua Qingwen in the treatment It has become a representative Chinese patent medicine for public health emergencies of the respiratory system. This systemic review will evaluate the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19. Web[Strength] 0.35g/capsule [Administration and Dosage] For oral administration, 4 capsules once, 3 times daily [Adverse Reactions] Unclear [Contraindications] Unclear [Precautions] 1. Teresa May Bandiola is a licensed pharmacist, a published writer, and a university instructor. 2022 Jan;20(1):26-33. doi: 10.1016/j.joim.2021.10.005. 1. 4.Patients with diabetes patients,high blood pressure, heart diseases, liver disease, kidney disease and other severe chronic diseases shall take medicine under guidance of physician. World Healthy Organization. [26]. Ding Y, Zeng L, Li R, et al. Follow her on Twitter via @sofiatomacruz. Hongtao Lei, Shutu Ma, Xiuxin Jiang, et al. Web[Administration and Dosage] For oral administration, 4 capsules once, 3 times a day. Traditional Chinese medicine Lianhua Qingwen treating corona virus disease 2019(COVID-19): Meta-analysis of randomized controlled trials. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. The authors have no conflicts of interest to disclose. SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD. Lianhua Qingwen, a representative TCM patent product for the treatment of influenza. [Functions and Indications]Clear heat and detoxify, remove lung hotness. The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by the national Wei Jian administration and the State Administration of traditional Chinese medicine for 20 times. Consult with doctors or pharmacists before administration if other medicines are received during this time. Delivery takes 2 business days & another 2 calendar days for order processingPROMO OFFER ( completed & over) : Buy 1 Bundle, We Donate 1 Bundle ! 94d329df351d7da8aefc2.shtml, https: //www.who.int/docs/default source/coronaviruse/situation-reports/20200325-sitrep-65-, https://www.jiyinzaixian.com/news/bNu5eb13ba6806e0, http://www.xinhuanet.com/politics/2020-03/24/c_1125757251.htm, http://www.nhc.gov.cn/yzygj/s7652m/202003/a31191442e29474b98bfed5579d5af95.shtml. In addition, we learned from the experience of Rhubarb in the treatise on Febrile Diseases in the treatment of epidemic diseases. The PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) checklist of this protocol is presented in PRISMA-P checklist. Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. Ephedrine isanamphetamine-like compound, which is an addictive stimulant of the central nervous system. Data is temporarily unavailable. [17]. Removes heat-toxin invasion of the lungs, including symptoms eg, fever, aversion to cold, muscle soreness, stuffy & runny nose. - China reported 11 new infections of the coronavirus on March 14, and for the first time since the start of the epidemic the majority of them were imported cases from overseas. Preliminary study on the inhibitory effect of three traditional Chinese medicine prescriptions on SARS related coronavirus in vitro [J]. Cao B, Wang Y, Wen D, et al. In 2012, Prevention and Treatment Scheme of Traditional Chinese Medicine for Type B Influenza, issued by the State Administration of Traditional Chinese Medicine Cao B, Zhang D, Wang C. A trial of lopinavir-ritonavir in, [6]. Kunming: Kunming University of technology; 2015. WebLianhua Qingwen Jiaonang with Chinese Characters; As per continuing post-marketing surveillance, there is still incessant sale and distribution even through social media platforms, such as Facebook, of Lianhua Qingwen Jiaonang with Chinese characters, which were verified as unregistered by the FDA. [20]. Before the evaluation results of this system are published, all databases will be retrieved again. Select all eligible studies published before May 8, 2020. 9 Experimental research also showed that LH exerted broad-spectrum effects on a series of influenza viruses by inhibiting viral propagation and regulating immune function. Qi Luo Lun [M]. Chinese herbal medicine 2008;31:12303. In accordance with the usage and dosage,the product should not be long term used. eCollection 2023. PRISMA flow diagram of study and exclusion. V03AX - Other therapeutic products ; Other products with therapeutic properties. [Description]Capsules, containing tan to brown granule and powder; odour, slightly aromatic; taste, slightly bitter. The independent Newcastle Ottawa scale was used to conduct methodological quality assessment of nonrandomized trials. WebTo evaluate the efficacy and safety of Lianhua Qingwen capsule for influenza. [32]. Medicine. Fish catch in Guimaras decreased by 29.6 percent from 7,844.53 metric tons in 2021 to 5,517 metric tons in 2022, as reported by the Chinese supplement Lianhua Qingwen: What you need to know, LOOK FOR BACKUP POWER: MORE Power assures 100% supply after weekend, Marcos prods NGCP to address energy woes in Western Visayas, Remains of two persons found dumped in concrete pipe, Guimaras fish yield down by 29.67% in 2022, DOE: Power reserves may run low in May, June, Globe secures ~P40.5B from its P91-B tower sale and leaseback, USTR keeps PH out of watchlist for 10 years, cites best, Iloilo taekwondo team hailed as overall champions in 2023 WVRAA meet, Gilas Pilipinas frontcourt woes continue as Aguilar & Erram ruled out, Kaya FC-Iloilo demolishes Mendiola FC in PFL clash, NBA Playoffs: Currys record-breaking 50-point Game 7 leads Warriors past Kings, Record-high 11,013 Filipino nurses took U.S. licensure exam for the first, Expert advice on identifying and treating allergic asthma, WHO and IAPAC sign a memorandum of understanding focused on ending, WHO launches new initiative to improve pandemic preparedness, 90% of countries report disruptions to essential health services since COVID-19 pandemic, Record-high 11,013 Filipino nurses took U.S. licensure exam for the first time in Q1, WHO and IAPAC sign a memorandum of understanding focused on ending epidemics in cities. Writing review & editing: Xiaolin Zhang. [18]. Keep away from animals and children.This product has not been evaluated by the FDA. In 2017, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (Version 1)(2017) , issued by the National Health and Family Planning Commission 2022 Aug 19;27(16):5292. doi: 10.3390/molecules27165292. [2] The main manifestations of the disease are fever, fatigue, and dry cough. Preliminary Study on the Inhibitory Effect of Lianhuaqingwen Capsule on Virus [D]. Upgrade to Rappler+ for exclusive content and unlimited access. If I2 test <50%, a fixed-effects model will be used to pool the data. Correct way is to take it orally, 3 capsules 1 time, 3 times a Traditional Chinese medicine, such as Lianhua Qingwen, has achieved some curative effect in many countries, but its effect is not clear. System searches CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as ChiCTR, NTR and clinical Trials.gov. How Lianhua Qingwen Jiaonang Capsule Help You Lianhua Qingwen Capsule for pneumonia The COVID-19 may improve the clinical symptoms associated with fever, cough, and fatigue. Already have Rappler+? Data curation: Xiaolin Zhang, Di Cao, Qi Zhang, Junnan Liu. FOIA Two reviewers (XLZ and JNL) will assess the eligibility of the studies retrieved during the searches independently using the inclusion and exclusion criteria. 11. Individuals w/ cold deficiencies in spleen & stomach or w/ qi. The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by The clinical data of 66 early-mid-stage COVID-19 patients admitted to hospitals in Guangzhou between January 2020 and April 2020 were retrospectively analyzed. Therefore, the completeness of the evidence is not yet available. [30] The I2 statistic of <50% indicates a low level of statistical heterogeneity, and that of 50% will be considered substantial statistical heterogeneity. National Key New Product Chinese Journal of viral diseases 2015;5:3524. Zhong said that, according to the experiment,the Lianhua Qingwen Jiaonang capsule can weakly inhibit the virus and repair cell injuries and inflammation caused by the virus. [2]. [Contraindications]Those who are allergic to this product and its ingredients should not take it. Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. 2023 Jan 12;17:11779322221149622. doi: 10.1177/11779322221149622. WebAs chemical analysis for quality control (QC) of traditional Chinese medicine (TCM) formula is difficult to guarantee the effectiveness, a bioassay method that combines QC with evaluation of therapeutic effects has been developed to assess the TCM quality. Efficacy and safety of Lian-Hua Qing-Wen granule for Careers. Dosage: 2 capsules twice a day ( after breakfast & dinner). Consume daily after meal As stated in the research paper published on "Scientific World Journal", Lianhua-Qingwen capsule (LQC) is a commonly used Chinese medical preparation to treat virus and especially played a very important role in the fight against severe acute respiratory syndrome (S-A-R-S) in 2002-2003 in China. GRADE: an emerging con- sensus on rating quality of evidence and strength of recommendations[J]. Lianhua Qingwen Dosage & Drug Information | MIMS Thailand Clipboard, Search History, and several other advanced features are temporarily unavailable. Avoid prolonged use. To add, theonline sale and distribution ofthis productis prohibited and those engaging in this activityviolatethe R.A.10918orPhilippine Pharmacy Act. Efficacy and safety of Lianhua Qingwen combined with : Medicine The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. We plan to carry out the following subgroup analyses if possible: the study area is different, the average course of disease is different, and the length of treatment is different. Correspondence: Mingjun Liu, and Xiaolin Zhang, professor, Changchun University of Chinese Medicine, 1035 Boshuo Road, Jingyue Economic Development Zone, Changchun City, Jilin Province 130117, China (e-mail: [emailprotected], [emailprotected]). Lianhuaqingwen (LH) is one of them, which is used to treat COVID-19 with a solid theoretical foundation in the field of TCM. Used in the patterns of heat toxin assailing the lung in influenza, manifested as fever or high fever, aversion to cold, muscular soreness, stuffy and runny nose, cough, headache, dry and sore throat, reddish tongue, yellow or yellow and greasy tongue coating. Tips: Please read the directions for use in retail or directed by physician. It cannot be bought over-the-counter and not recommended for self-medication. The novel coronavirus pneumonia (COVID-19) has spread to >200 countries and regions. The following data will then be extracted from the studies selected for inclusion using a data collection form, and recorded onto an Excel file: first author and year, study design, sample, intervention, type of measures, risk of bias assessment, and findings. The protocol will be disseminated in a peer-reviewed journal or presented at a relevant conference. New Chinese medicine and clinical pharmacology 2007;18:69. Journal of Central South University for Nationalities: Natural Science Edition 2012;31:204. [33] Previous pharmacodynamic studies have confirmed that Lianhua Qingwen capsule can significantly inhibit the SARS CoV virus in cultured cells in vitro, and has a significant inhibitory effect on H1N1, H3N2, h7n9, and other influenza viruses,[3436] indicating that Lianhua Qingwen capsule has played an important role in the prevention and control of public health events of respiratory system caused by virus. See this image and copyright information in PMC. Placebo, routine western medicine therapy, and other therapeutic methods in the comparators (drugs, dose, frequency, duration); (5) Outcomes: the primary outcomes include total efficiency, primary symptoms, and modify the keyword list to augment your search. For NRIs, evaluate its methodological quality with the Newcastle Ottawa scale (NOS). Copyright 2023 MIMS Pte Ltd. All rights reserved. This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, disappearance rate of cough symptoms, disappearance rate of asthenia symptoms, and adverse drug events. Consumption Directions: Recommended daily intake: 3 times daily. http://creativecommons.org/licenses/by/4.0. PLoS One. Also,its packaging is in Chinese characters and needs to comply with FDAs labeling requirements written in English. CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment, MeSH Just because a supplement is derived from natural sources does not mean it is safe. Bioinform Biol Insights. BackgroundLHQW's formulation is based on two ancient formulae from the Han and Qing dynasties - Maxing Shigan decoction and Yinqiao powder - following the SARS epidemic. Effect of Lianhuaqingwen Capsule on lung index of mice infected with virus [J]. 2020 Sep 11;15(9):e0238828. Philippines FDA approved LHQW for the treatment of mild Covid-19. Click to view Lianhua Qingwen detailed prescribing information Overdosage View Lianhua Qingwen Lianhua Qingwen formula is based on the theory of collateral disease, to reveal the law of transmission of respiratory infectious diseases caused by virus. Shunya Zhu, Xiaoying Li, Yunling Wei, et al. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. Do not give during pregnancy & lactation, & in childn. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. Abbreviations: BAs = comparison before and after the study, C0VID-19 = Corona Virus Disease 2019, ChiCTR = China Clinical Trial Registration Center, MERS = Middle East respiratory syndrome, NOS = Newcastle Ottawa scale, NTR = Netherlands National Trial Registration Center, PRISMA-P = Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, RCTs = randomized controlled trials, RCSs = retrospective cohort study. Bookshelf 13. TheDangerous Drug Board (DDB)considers ephedrine as a dangerous drug, andthose found to be sources are also classified as dangerous drugs. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as Siwen Tang, Yanfen Zhang, Kejian Liu, et al. Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. and transmitted securely. When you buyLHQW from us, actsmarket.com will donate the same number of boxes to needy seniors above 50 years old, living in 1-room or 2-room rental flats in Singapore, cap at 140 bundles or 700 boxes. [Administration and Dosage]For oral administration, 4 capsules once, 3 times daily. Identification of a Pharmacological Biomarker Published by Wolters Kluwer Health, Inc. 1. general information: title, authors, year of publication, and Study area, average age, average course of disease and treatment time; 2. trial characteristics: design, duration of follow-up, method of randomization, allocation concealment, incomplete outcome data, blinding (patients, people administering treatment, outcome assessors); 3. intervention(s): intervention(s) (The dosage form of.
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